%0 Journal Article %T 2020 European guideline on the management of syphilis. %A Janier M %A Unemo M %A Dupin N %A Tiplica GS %A Potočnik M %A Patel R %J J Eur Acad Dermatol Venereol %V 35 %N 3 %D Mar 2021 %M 33094521 %F 9.228 %R 10.1111/jdv.16946 %X The 2020 edition of the European guideline on the management of syphilis is an update of the 2014 edition. Main modifications and updates include: -The ongoing epidemics of early syphilis in Europe, particularly in men who have sex with men (MSM) -The development of dual treponemal and non-treponemal point-of-care (POC) tests -The progress in non-treponemal test (NTT) automatization -The regular episodic shortage of benzathine penicillin G (BPG) in some European countries -The exclusion of azithromycin as an alternative treatment at any stage of syphilis -The pre-exposure or immediate post-exposure prophylaxis with doxycycline in populations at high risk of acquiring syphilis.