%0 Case Reports
%T A Rare Case of Peripheral Nerve Hyperexcitability in Childhood: Isaacs Syndrome.
%A Kanmaz S
%A Özcan M
%A Şimşek E
%A Serin HM
%A Aydogdu İ
%A Gökben S
%A Tekgül H
%J J Pediatr Neurosci
%V 15
%N 2
%D Apr-Jun 2020
%M 33042252
暂无%R 10.4103/jpn.JPN_128_19
%X Isaacs syndrome is rare disorder with peripheral nerve hyperexcitability syndromes with acquired neuromyotonia in childhood. We present a 13-year-old girl with muscle stiffness and neuromyotonia diagnosed Isaac syndrome with spontaneous discharge potentials on motor unit in electromyography and the diagnosis supported by the presence of antinuclear antibodies. A successful treatment was obtained using low-dose carbamazepine. Cause of Isaacs syndrome is unknown, generally thought to be an autoimmune etiology with voltage-gated potassium channelopathy; it sometimes occurs as a paraneoplastic syndrome. Early use of electromyography has critical role in the differential diagnosis with certain muscle disorders and peripheral nerve hyperexcitability syndromes.