%0 Journal Article
%T Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition.
%A Francisco J
%A Zhang Y
%A Jeong JI
%A Mizushima W
%A Ikeda S
%A Ivessa A
%A Oka S
%A Zhai P
%A Tallquist MD
%A Del Re DP
%J JACC Basic Transl Sci
%V 5
%N 9
%D Sep 2020
%M 33015415
%F 9.531
%R 10.1016/j.jacbts.2020.07.009
%X Fibrotic remodeling of the heart in response to injury contributes to heart failure, yet therapies to treat fibrosis remain elusive. Yes-associated protein (YAP) is activated in cardiac fibroblasts by myocardial infarction, and genetic inhibition of fibroblast YAP attenuates myocardial infarction-induced cardiac dysfunction and fibrosis. YAP promotes myofibroblast differentiation and associated extracellular matrix gene expression through engagement of TEA domain transcription factor 1 and subsequent de novo expression of myocardin-related transcription factor A. Thus, fibroblast YAP is a promising therapeutic target to prevent fibrotic remodeling and heart failure.