%0 Case Reports
%T Diffuse-type tenosynovial giant cell tumor of the temporomandibular joint with skull base invasion: a report of 22 cases with literature review.
%A Liu Y
%A Fan BH
%A Tan YR
%A Zhu DW
%A Dong MJ
%A Wang LZ
%A Li J
%A Sun J
%A Zhang CP
%A Ji T
%A Yang WJ
%A Abdelrehem A
%A Wu YQ
%A Zhong LP
%J Oral Surg Oral Med Oral Pathol Oral Radiol
%V 131
%N 1
%D Jan 2021
%M 32981877
暂无%R 10.1016/j.oooo.2020.08.013
%X <B>OBJECTIVE: </B>The aim of this study was to retrospectively analyze the clinical characteristics, surgical treatment, and prognosis of patients with diffuse-type tenosynovial giant cell tumor (D-TGCT) involving the temporomandibular joint (TMJ) and the skull base.<BR><B>METHODS: </B>A retrospective study was performed in patients with D-TGCT involving the TMJ and the skull base at our institute from April 2009 to August 2018. Data on clinical characteristics, surgical treatment, and prognosis were collected and analyzed. A literature search on D-TGCT involving the TMJ was conducted and the data analyzed.<BR><B>RESULTS: </B>The study included 22 patients (14 males and 8 females), with an average age of 44 years. The main symptoms were headache and hearing limitation, accompanied by a swelling in the TMJ area. Magnetic resonance imaging (MRI) showed low signals on T1- and T2-weighted images. All lesions were completely removed. Temporal bone flap, titanium mesh, and temporal muscle flap were used for reconstruction. The recurrence rate was 4.5%. In the literature, 115 cases were reported. Surgery alone was performed in 88 cases; postoperative radiotherapy was performed in 19 cases; the tumor recurrence rates were 9.1% and 15.8% for the 2 procedures, respectively. All patients were alive at the end of the follow-up period.<BR><B>CONCLUSIONS: </B>D-TGCT involving the TMJ and the skull base is a locally aggressive but benign lesion necessitating complete resection and has a good prognosis.