%0 Journal Article
%T Optimal Maturation of the SIV-Specific CD8+ T Cell Response after Primary Infection Is Associated with Natural Control of SIV: ANRS SIC Study.
%A Passaes C
%A Millet A
%A Madelain V
%A Monceaux V
%A David A
%A Versmisse P
%A Sylla N
%A Gostick E
%A Llewellyn-Lacey S
%A Price DA
%A Blancher A
%A Dereuddre-Bosquet N
%A Desjardins D
%A Pancino G
%A Le Grand R
%A Lambotte O
%A Müller-Trutwin M
%A Rouzioux C
%A Guedj J
%A Avettand-Fenoel V
%A Vaslin B
%A Sáez-Cirión A
%J Cell Rep
%V 32
%N 12
%D 09 2020 22
%M 32966788
暂无%R 10.1016/j.celrep.2020.108174
%X Highly efficient CD8+ T cells are associated with natural HIV control, but it has remained unclear how these cells are generated and maintained. We have used a macaque model of spontaneous SIVmac251 control to monitor the development of efficient CD8+ T cell responses. Our results show that SIV-specific CD8+ T cells emerge during primary infection in all animals. The ability of CD8+ T cells to suppress SIV is suboptimal in the acute phase but increases progressively in controller macaques before the establishment of sustained low-level viremia. Controller macaques develop optimal memory-like SIV-specific CD8+ T cells early after infection. In contrast, a persistently skewed differentiation phenotype characterizes memory SIV-specific CD8+ T cells in non-controller macaques. Accordingly, the phenotype of SIV-specific CD8+ T cells defined early after infection appears to favor the development of protective immunity in controllers, whereas SIV-specific CD8+ T cells in non-controllers fail to gain antiviral potency, feasibly as a consequence of early defects imprinted in the memory pool.