%0 Journal Article
%T Human NINEIN polymorphism at codon 1111 is associated with the risk of colorectal cancer.
%A Yasuda Y
%A Sakai A
%A Ito S
%A Sasai K
%A Ishizaki A
%A Okano Y
%A Kawahara S
%A Jitsumori Y
%A Yamamoto H
%A Matsubara N
%A Shimizu K
%A Katayama H
%J Biomed Rep
%V 13
%N 5
%D Nov 2020
%M 32934817
暂无%R 10.3892/br.2020.1352
%X NINEIN serves an essential role in centrosome function as a microtubule organizing center, and in the reformation of the interphase centrosome architecture following mitosis. In the present study, the association between NINEIN Pro1111Ala (rs2236316), a missense single nucleotide polymorphism, and the risk of colorectal cancer (CRC), related to smoking and alcohol consumption habits in 200 patients with CRC and 1,141 cancer-free control participants were assessed in a case-control study performed in Japan. The results showed that the NINEIN Ala/Ala genotype compared with the Pro/Pro genotype was significantly more associated with an increased risk of CRC, and the males with the Ala/Ala genotype exhibited a significantly increased risk of CRC compared with those with Pro/Pro and Pro/Ala genotypes. Stratified analyses of the Ala/Ala genotype with CRC risk further showed an increased association in never/light drinkers (<23 g of ethanol/day), in male never/light drinkers and in male patients with rectal cancer. These findings suggest that the genetic variant of the NINEIN Pro1111Ala polymorphism has a significant effect on CRC susceptibility in the Japanese population.