%0 Journal Article
%T Subclinical decrease in cardiac autonomic and diastolic function in patients with metabolic disorders: HSCAA study.
%A Morimoto A
%A Kadoya M
%A Kakutani-Hatayama M
%A Kosaka-Hamamoto K
%A Miyoshi A
%A Shoji T
%A Goda A
%A Asakura M
%A Koyama H
%J Metabol Open
%V 5
%N 0
%D Mar 2020
%M 32812948
暂无%R 10.1016/j.metop.2020.100025
%X Heart failure due to decreased diastolic function, HFpEF, is a growing health concern with rising prevalence. We examined subclinical cardiac autonomic and diastolic functions in 605 patients with metabolic diseases classified as pre-heart failure. Presence of glucose intolerance or diabetes, or visceral adiposity was significantly associated with reduced cardiac autonomic and diastolic functions. Higher autonomic functions were significantly associated with a parameter of better cardiac diastolic function (E/A) (SDNN: r = 0.306, p < 0.01; HF: r = 0.341, p < 0.01), with the association independent of diabetes, body mass index, visceral adiposity and insulin resistance index. Thus, reduced autonomic function may be a potential predictor for decreased cardiac diastolic functions in metabolic disorders.