%0 Journal Article
%T Placental growth factor in suspected preterm pre-eclampsia: a review of the evidence and practicalities of implementation.
%A Hurrell A
%A Beardmore-Gray A
%A Duhig K
%A Webster L
%A Chappell LC
%A Shennan AH
%J BJOG
%V 127
%N 13
%D 12 2020
%M 32701207
%F 7.331
%R 10.1111/1471-0528.16425
%X Despite extensive research, the pathophysiology and prevention of pre-eclampsia remain elusive, diagnosis is challenging, and pre-eclampsia remains associated with adverse maternal and perinatal outcomes. Angiogenic biomarkers, including placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1), have been identified as valuable biomarkers for preterm pre-eclampsia, accelerating diagnosis and reducing maternal adverse outcomes by risk stratification, with enhanced surveillance for high-risk women. PlGF-based testing is increasingly being implemented in clinical practice in several countries. This review provides healthcare providers with an understanding of the evidence for PlGF-based testing and describes the practicalities and challenges to implementation. TWEETABLE ABSTRACT: Placental growth factor in pre-eclampsia: evidence and implementation of testing.