%0 Journal Article
%T Antileishmanial activity of long chain alkyl benzene and other constituents from seeds of Sesamum indicum. L (Pedaliaceae).
%A Ma'mag LK
%A Zintchem AAA
%A Atchadé AT
%A Kopa Kowa T
%A Tchinda Tiabou A
%A Bikobo DSN
%A Pegnyemb DE
%J Nat Prod Res
%V 35
%N 23
%D Dec 2021
%M 32657142
%F 2.488
%R 10.1080/14786419.2020.1793147
%X The methanolic extract of the waste seeds of Sesamum indicum L. (Pedaliaceae) was subjected to chromatographic fractionation; it led to the isolation of an alkyl benzene identified as 1,3-bis (pentadecyl)benzene (1) along with three known fatty acids: oleic acid (2), linoleic acid (3), and palmitic acid (4); one monosaturated cardanol, 3-pentadecylphenol (5) and two phytosteroids identified as sitostanol (6) and campestanol (7). The structures of these compounds were elucidated by chemical and spectroscopic analyses. Compounds 1, 5 and 6 were evaluated against protozoan parasites. Compound 1 moderately inhibited the promastigote form of Leishmania donovani LG13 with IC50 equal to 16.9 μM.