%0 Case Reports
%T A young male with chronic nonproductive cough diagnosed with blastomycosis in China: a case report.
%A Wang N
%A Luo Z
%A Deng S
%A Li Q
%J BMC Pulm Med
%V 20
%N 1
%D Jul 2020 11
%M 32652975
%F 3.32
%R 10.1186/s12890-020-01225-4
%X <B>BACKGROUND: </B>Blastomycosis is a fungal infectious disease prevalent in North America and rarely reported in Asia. Misdiagnosis of malignancy and other infectious diseases were reported.<BR><B>METHODS: </B>A 24-years-old male patient presented with chronic non-productive cough of 4 months duration. He had been diagnosed with Mycobacterium tuberculosis infection and lung malignancy elsewhere and presented to us as the symptoms persisted. We offered him the biopsy under endobronchial ultrasound-guide sheath-transbronchial lung biopsy and sample specimen were sent for next generation sequencing analysis, returned as Blastomyces Dermatitidis infection. The patient was treated by itraconazole for 6 months, his symptoms decreased significantly and the CT scan showed resolution of the lesion.<BR><B>CONCLUSIONS: </B>We shared a case of blastomycosis with delayed and difficult diagnosis and reviewed the knowledge regarding differential diagnosis and next generation sequencing technologies.