%0 Journal Article
%T Short Communication: HIV-1 Drug Resistance Mutation Analyses of Cameroon-Derived Integrase Sequences.
%A Mikasi SG
%A Isaacs D
%A Ikomey GM
%A Shimba H
%A Cloete R
%A Jacobs GB
%J AIDS Res Hum Retroviruses
%V 37
%N 1
%D 01 2021
%M 32640829
%F 1.723
%R 10.1089/AID.2020.0022
%X HIV-1 integrase (IN) is a primary target for combination antiretroviral therapy. Only a limited number of studies report on the emergence of resistance-associated mutations (RAMs) in Cameroon. We observed that 1.4% of sequence from treatment-naive patients had IN strand transfer inhibitor (INSTI) RAMs. These mutations confer resistance to raltegravir and elvitegravir. We also observed that 10.1% of the sequences have INSTI accessory RAMs. HIV-1 CRF02_AG was the predominant subtype (44.7%) in this study analyses. The occurrence of INSTI RAMs among the sequences at baseline needs to be monitored carefully.