%0 Journal Article
%T Detection rate, pattern of relapse and influence on therapeutic decision of PSMA PET/CT in patients affected by biochemical recurrence after radical prostatectomy, a retrospective case series.
%A Francolini G
%A Detti B
%A Bottero M
%A Zilli T
%A Lancia A
%A Bruni A
%A Borghesi S
%A Mariotti M
%A Castellucci P
%A Fanti S
%A Filippi AR
%A Teriaca MA
%A Maragna V
%A Aristei C
%A Mazzeo E
%A Livi L
%A Ingrosso G
%J Clin Transl Oncol
%V 23
%N 2
%D Feb 2021
%M 32602076
%F 3.34
%R 10.1007/s12094-020-02427-2
%X <B>OBJECTIVE: </B>68Ga-Prostate-specific membrane antigen (PSMA) PET/CT is widely used in patients with biochemical recurrence (BCR) after radical prostatectomy. We collected data about patients staged with PSMA PET/CT after BCR (PSA < 1 ng/ml) in four different institutes. Impact of baseline features (Gleason score, risk classification, PSA at recurrence, PSA doubling time and time to recurrence) was explored to understand predictive factors of (PSMA) PET/CT positivity. Impact of restaging on following treatment approaches was reported.<BR><B>RESULTS: </B>92 patients were included. PSMA PET/CT detection rate was 56.5% and low-volume disease (≤ 3 non-visceral lesions) was detected in 52.2% of patients. After positive scan, 13.5% of patients still lies on observation, ADT alone was administered in 30.8% of cases, Stereotactic body RT (SBRT) alone was delivered to 44.2% of patients and 11.5% of patients underwent concomitant SBRT and ADT. Seven patients underwent conventional salvage prostate bed RT. Chi-squared test showed a higher rate of positive PSMA PET/CT for patients with Gleason score > 7 (p = 0.004) and TTR < 29.5 months (p = 0.003).<BR><B>CONCLUSIONS: </B>PSMA PET/CT showed a high detection rate. This influenced clinical management in a significant percentage of patients, allowing treatment tailoring on the basis of imaging.