%0 Comparative Study
%T Association of high-risk coronary atherosclerosis at CCTA with clinical and circulating biomarkers: Insight from CAPIRE study.
%A Conte E
%A Andreini D
%A Magnoni M
%A Masson S
%A Mushtaq S
%A Berti S
%A Canestrari M
%A Casolo G
%A Gabrielli D
%A Latini R
%A Marraccini P
%A Moccetti T
%A Modena MG
%A Pontone G
%A Gorini M
%A Maggioni AP
%A Maseri A
%A  
%A  
%A  
%A  
%A  
%A  
%J J Cardiovasc Comput Tomogr
%V 15
%N 1
%D Jan-Feb 2021
%M 32563713
暂无%R 10.1016/j.jcct.2020.03.005
%X <B>BACKGROUND: </B>High-risk coronary atherosclerosis features evaluated coronary CT angiography (CCTA) were suggested to have a prognostic role. The present study aimed to evaluate the association of circulating biomarkers with high-risk plaque features assessed by CCTA.<BR><B>METHODS: </B>A consecutive cohort of subjects who underwent CCTA because of suspected CAD was screened for inclusion in the CAPIRE study. Based on risk factors (RF) burden patients were defined as having a low clinical risk (0-1 RF with the exclusion of patients with diabetes mellitus as single RF) or an high clinical risk (≥3 RFs). In all patients, measurement of inflammatory biomarkers and CCTA analysis focused on high-risk plaque features were performed. Univariate and multivariate logistic regression analysis were used to evaluate the relationship between clinical and biological variables with CCTA advanced plaque features.<BR><B>RESULTS: </B>528 patients were enrolled in CAPIRE study. Older age and male sex appeared to be predictors of qualitative high-risk plaque features and associated with the presence of elevated total, non-calcified and low-attenuation plaque volume. Among circulating biomarkers only hs-CRP was found to be associated with qualitative high-risk plaque features (OR 2.02, p = 0.004 and 2.02, p = 0.012 for LAP and RI > 1.1, respectively) with borderline association with LAP-Vol (OR 1.52, p = 0.076); HbA1c and PTX-3 resulted to be significantly associated with quantitative high-risk plaque features (OR 1.71, p = 0.003 and 1.04, p = 0.002 for LAP-Vol, respectively).<BR><B>CONCLUSIONS: </B>Our results support the association between inflammatory biomarkers (hs-CRP, PTX- 3), HbA1c and high-risk atherosclerotic features detected by CCTA. Male sex and older age are significant predictors of high-risk atherosclerosis.