%0 Journal Article
%T Quinoxaline Derivatives as Antiviral Agents: A Systematic Review.
%A Montana M
%A Montero V
%A Khoumeri O
%A Vanelle P
%J Molecules
%V 25
%N 12
%D Jun 2020 16
%M 32560203
%F 4.927
%R 10.3390/molecules25122784
%X <B>BACKGROUND: </B>In recent decades, several viruses have jumped from animals to humans, triggering sizable outbreaks. The current unprecedent outbreak SARS-COV-2 is prompting a search for new cost-effective therapies to combat this deadly pathogen. Suitably functionalized polysubstituted quinoxalines show very interesting biological properties (antiviral, anticancer, and antileishmanial), ensuring them a bright future in medicinal chemistry.<BR><B>OBJECTIVE: </B>Focusing on the promising development of new quinoxaline derivatives as antiviral drugs, this review forms part of our program on the anti-infectious activity of quinoxaline derivatives.<BR><B>METHODS: </B>Study compiles and discusses recently published studies concerning the therapeutic potential of the antiviral activity of quinoxaline derivatives, covering the literature between 2010 and 2020.<BR><B>RESULTS: </B>A final total of 20 studies included in this review.<BR><B>CONCLUSIONS: </B>This review points to a growing interest in the development of compounds bearing a quinoxaline moiety for antiviral treatment. This promising moiety with different molecular targets warrants further investigation, which may well yield even more encouraging results regarding this scaffold.