%0 Case Reports
%T [Fatal intracerebral hemorrhage in a patient with chronic neutrophilic leukemia: About one case and literature review].
%A Talon L
%A de Renzis B
%A Fiore M
%A Sanhes L
%A Sapin AF
%A Berger M
%A Sinègre T
%A Lebreton A
%J Rev Med Interne
%V 41
%N 8
%D Aug 2020
%M 32362366
%F 0.885
%R 10.1016/j.revmed.2020.03.012
%X <B>BACKGROUND: </B>Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative syndrome characterized by a significant increase in mature neutrophils. One of the most serious complications is the occurrence of bleeding events, which may sometimes lead to death.<BR><B>METHODS: </B>A 75-year-old patient presented with CNL, complicated by a severe bleeding phenotype. Biological investigations revealed platelet function defect and increase in neutrophil elastase. The follow-up was marked by an intracranial hemorrhage leading to the patient's death 7 months after diagnosis.<BR><B>CONCLUSIONS: </B>This bleeding phenotype has been reported several times in patients with CNL. However, the pathophysiological mechanisms that cause bleeding are not yet fully understood.