%0 Journal Article
%T Nanopore Sequencing in Blood Diseases: A Wide Range of Opportunities.
%A Minervini CF
%A Cumbo C
%A Orsini P
%A Anelli L
%A Zagaria A
%A Specchia G
%A Albano F
%J Front Genet
%V 11
%N 0
%D 2020
%M 32140171
%F 4.772
%R 10.3389/fgene.2020.00076
%X The molecular pathogenesis of hematological diseases is often driven by genetic and epigenetic alterations. Next-generation sequencing has considerably increased our genomic knowledge of these disorders becoming ever more widespread in clinical practice. In 2012 Oxford Nanopore Technologies (ONT) released the MinION, the first long-read nanopore-based sequencer, overcoming the main limits of short-reads sequences generation. In the last years, several nanopore sequencing approaches have been performed in various "-omic" sciences; this review focuses on the challenge to introduce ONT devices in the hematological field, showing advantages, disadvantages and future perspectives of this technology in the precision medicine era.