%0 Journal Article
%T Implications of new understandings of gliomas in children and adults with NF1: report of a consensus conference.
%A Packer RJ
%A Iavarone A
%A Jones DTW
%A Blakeley JO
%A Bouffet E
%A Fisher MJ
%A Hwang E
%A Hawkins C
%A Kilburn L
%A MacDonald T
%A Pfister SM
%A Rood B
%A Rodriguez FJ
%A Tabori U
%A Ramaswamy V
%A Zhu Y
%A Fangusaro J
%A Johnston SA
%A Gutmann DH
%J Neuro Oncol
%V 22
%N 6
%D 06 2020 9
%M 32055852
%F 13.029
%R 10.1093/neuonc/noaa036
%X Gliomas are the most common primary central nervous system tumors occurring in children and adults with neurofibromatosis type 1 (NF1). Over the past decade, discoveries of the molecular basis of low-grade gliomas (LGGs) have led to new approaches for diagnosis and treatments. However, these new understandings have not been fully applied to the management of NF1-associated gliomas. A consensus panel consisting of experts in NF1 and gliomas was convened to review the current molecular knowledge of NF1-associated low-grade "transformed" and high-grade gliomas; insights gained from mouse models of NF1-LGGs; challenges in diagnosing and treating older patients with NF1-associated gliomas; and advances in molecularly targeted treatment and potential immunologic treatment of these tumors. Next steps are recommended to advance the management and outcomes for NF1-associated gliomas.