%0 Journal Article
%T Trabecular bone scores in young HIV-infected men: a matched case-control study.
%A Kim YJ
%A Kang KY
%A Shin J
%A Jun Y
%A Kim SI
%A Kim YR
%J BMC Musculoskelet Disord
%V 21
%N 1
%D Feb 2020 10
%M 32041580
%F 2.562
%R 10.1186/s12891-020-3092-0
%X <B>BACKGROUND: </B>Screening for osteoporosis with dual-energy X-ray absorptiometry (DXA) is recommended for male HIV-infected patients only above the age of 50. Recently, trabecular bone score (TBS) has been introduced as a novel tool to assess bone microarchitecture using DXA of the lumbar spine. Few studies have reported TBS values in HIV-infected individuals younger than 50 years of age. This study compared TBS values in young males infected with HIV and matched controls, and investigated the associations between TBS and demographic parameters, clinical parameters, and bone mineral density (BMD) scores.<BR><B>METHODS: </B>A cross-sectional study of BMD and TBS in HIV-infected men (n = 80) aged between 18 and 50 years and age- and sex-matched controls (n = 80) was conducted.<BR><B>RESULTS: </B>The proportion of patients with low BMD (Z-score ≤ - 2) was significantly greater among HIV-infected patients than among matched controls (21.3% [17/80] vs. 8.8% [7/80], p = 0.027). Mean TBS values were significantly lower in HIV-infected patients than in controls (1.41 ± 0.07 vs. 1.45 ± 0.07, p = 0.008). In both groups, TBS values were positively correlated with BMD at the lumbar spine, femoral neck, and total hip (p < 0.001); however, TBS was not correlated with body mass index. In the HIV group, TBS was negatively correlated with the duration of tenofovir disoproxil fumarate(TDF) exposure (p = 0.04).<BR><B>CONCLUSIONS: </B>Young men infected with HIV had abnormal bone trabecular microarchitecture, as assessed by both TBS and BMD. TBS values were correlated with both BMD and the duration of TDF exposure.