%0 Clinical Trial
%T Immunosuppressive therapy for elderly-acquired pure red cell aplasia: cyclosporine A may be more effective.
%A Liu X
%A Lu X
%A Chen L
%A Yang Y
%A Wu X
%A Lu R
%A Wang S
%A Zhang J
%A Hong M
%A Zhu Y
%A He G
%A Li J
%J Ann Hematol
%V 99
%N 3
%D Mar 2020
%M 31970447
%F 4.03
%R 10.1007/s00277-020-03926-6
%X This current study retrospectively analyzed the clinical characteristics of 69 adult patients with acquired pure red cell aplasia (PRCA) including 40 elderly and 29 non-elderly patients from September 2009 to June 2019. The remission induction therapy regimens included cyclosporine A (CsA), corticosteroids (CS), or other immunosuppressive agents. The overall response rate was 55% (22/40) in the elderly group compared with 75.9% (22/29) in non-elderly patients (P = 0.075). In elderly patients, the best remission was achieved in the group treated with CsA than those treated with CS or other immunosuppressive agents (83.3% vs 26.7% vs 42.9%%, P = 0.004). However, outcomes of remission were similar among different treatment groups (P = 0.458) in non-elderly patients. CS induced a higher response rate in the non-elderly than that in the elderly (88.9% vs 26.7%, P = 0.009). By univariate and multivariate analysis, the clinical efficacy of elderly patients with acquired PRCA was closely associated with an induction regimen of CsA (P = 0.009; P = 0.017). In conclusion, CsA might produce higher response rate than CS and other drugs in elderly patients with acquired PRCA.