%0 Journal Article
%T Studying Peripheral T Cell Homeostasis in Mice: A Concise Technical Review.
%A Moutuou MM
%A Gauthier SD
%A Chen N
%A Leboeuf D
%A Guimond M
%J Methods Mol Biol
%V 2111
%N 0
%D 2020
%M 31933214
暂无%R 10.1007/978-1-0716-0266-9_21
%X For several years, it was believed that the thymus was entirely responsible for maintaining T cell homeostasis. Today, it is well-known that homeostatic peripheral mechanisms are essential in order to maintain T cell numbers and diversity constant in the periphery. Naïve and memory T cells require continual access to self-peptide MHC class I and II molecules and/or cytokines to survive in the periphery. Under normal conditions, homeostatic resources are low, and lymphocytes undergo very slow proliferation and survive. Following T cell depletion, the bioavailability of homeostatic resources is significantly increased, and T cell proliferation is dramatically augmented. The development of lymphopenic mouse models has helped our current understanding of factors involved in the regulation of peripheral T cell homeostasis. In this minireview, we will give a brief overview about basic techniques used to study peripheral T cell homeostasis in mice.