%0 Journal Article
%T Induction of Tolerance and Immunity by Dendritic Cells: Mechanisms and Clinical Applications.
%A Fucikova J
%A Palova-Jelinkova L
%A Bartunkova J
%A Spisek R
%J Front Immunol
%V 10
%N 0
%D 2019
%M 31736936
%F 8.786
%R 10.3389/fimmu.2019.02393
%X Dendritic cells (DCs) are key regulators of immune responses that operate at the interface between innate and adaptive immunity, and defects in DC functions contribute to the pathogenesis of a variety of disorders. For instance, cancer evolves in the context of limited DC activity, and some autoimmune diseases are initiated by DC-dependent antigen presentation. Thus, correcting aberrant DC functions stands out as a promising therapeutic paradigm for a variety of diseases, as demonstrated by an abundant preclinical and clinical literature accumulating over the past two decades. However, the therapeutic potential of DC-targeting approaches remains to be fully exploited in the clinic. Here, we discuss the unique features of DCs that underlie the high therapeutic potential of DC-targeting strategies and critically analyze the obstacles that have prevented the full realization of this promising paradigm.