%0 Case Reports
%T Case report of delayed seroprotection rather than non-response after primary three-dose hepatitis B vaccination.
%A Koc ÖM
%A Damoiseaux J
%A van Loo IHM
%A Masquillier HIL
%A Oude Lashof AML
%J Vaccine
%V 38
%N 2
%D 01 2020 10
%M 31648909
%F 4.169
%R 10.1016/j.vaccine.2019.10.022
%X We describe a delayed hepatitis B seroprotection 12 weeks after the primary vaccination schedule in a 57-year-old male with smoldering multiple myeloma. Based on undetectable anti-HBs antibodies 6 weeks after the third vaccination, the index person was previously considered to be a hepatitis B vaccine non-responder. Because hepatitis B vaccination started in the 1980s, many hepatitis B vaccine non-responders have received a revaccination regimen. If more cases of genuine delayed hepatitis B seroprotection surface in patients with hematologic malignancies, delayed seroprotection should be considered before the commencement of hepatitis B revaccination.