%0 Journal Article
%T Central Hepatic Regenerative Nodules in Alagille Syndrome: A Clinicopathological Review.
%A Andrews AR
%A Putra J
%J Fetal Pediatr Pathol
%V 40
%N 1
%D Feb 2021
%M 31608763
%F 1.412
%R 10.1080/15513815.2019.1675834
%X <B>UNASSIGNED: </B>This review aims to highlight the clinicopathological characteristics and differential diagnosis of central hepatic regenerative nodules (CHRNs) in patients with Alagille syndrome.<BR><B>UNASSIGNED: </B>A review of the literature for cases of CHRNs and their differential diagnoses in patients with Alagille syndrome was performed and the main findings were collated.<BR><B>UNASSIGNED: </B>Large, regenerative hepatic nodules are seen in approximately 30% of patients with Alagille syndrome. They are thought to be a functional adaptation to vascular changes rather than a neoplastic process. The nodules are typically centrally located, and normal hepatic vasculature coursing through the lesions are noted radiologically. Microscopically, they are characterized by well-circumscribed hepatic lesions with preserved architecture, lesser degrees of fibrosis and relative preservation of interlobular bile ducts compared to the background cirrhotic liver.<BR><B>UNASSIGNED: </B>Regenerative nodules are common in Alagille's syndrome, and should be distinguished from hepatocellular carcinomas and adenomas for appropriate management and prognostication.