%0 Journal Article
%T NOD-like receptor signaling in inflammation-associated cancers: From functions to targeted therapies.
%A Liu P
%A Lu Z
%A Liu L
%A Li R
%A Liang Z
%A Shen M
%A Xu H
%A Ren D
%A Ji M
%A Yuan S
%A Shang D
%A Zhang Y
%A Liu H
%A Tu Z
%J Phytomedicine
%V 64
%N 0
%D Nov 2019
%M 31465982
%F 6.656
%R 10.1016/j.phymed.2019.152925
%X <B>BACKGROUND: </B>Recently, many studies have reported that some botanicals and natural products were able to regulate NOD-like receptor signaling. NOD-like receptors (NLRs) have been established as crucial regulators in inflammation-associated tumorigenesis, angiogenesis, cancer cell stemness and chemoresistance. NLRs specifically sense pathogen-associated molecular patterns and respond by activating other signaling regulators, including Rip2 kinase, NF-κB, MAPK and ASC/caspase-1, leading to the secretion of various cytokines.<BR><B>OBJECTIVE: </B>The aim of this article is to review the molecular mechanisms of NOD-like receptor signaling in inflammation-associated cancers and the NLRs-targeted botanicals and synthetic small molecules in cancer intervention.<BR><B>RESULTS: </B>Aberrant activation of NLRs occurs in various cancers, orchestrating the tissue microenvironment and potentiating neoplastic risk. Blocking NLR inflammasome activation by botanicals or synthetic small molecules may be a valuable way to prevent cancer progression. Moreover, due to the roles of NLRs in regulating cytokine production, NLR signaling may be correlated with senescence-associated secretory phenotype.<BR><B>CONCLUSIONS: </B>In this review, we discuss how NLR signaling is involved in inflammation-associated cancers, and highlight the NLR-targeted botanicals and synthetic small molecules in cancer intervention.