%0 Journal Article
%T Identifying crucial genes for prognosis in septic patients: Gene integration study based on PRISMA guidelines.
%A Hu Y
%A Zhong W
%A Chen M
%A Zhang Q
%J Medicine (Baltimore)
%V 98
%N 33
%D Aug 2019
%M 31415393
%F 1.817
%R 10.1097/MD.0000000000016807
%X <B>BACKGROUND: </B>Sepsis is a serious clinical condition with a poor prognosis, despite improvements in diagnosis and treatment.Therefore, novel biomarkers are necessary that can help with estimating prognosis and improving clinical outcomes of patients with sepsis.<BR><B>METHODS: </B>The gene expression profiles GSE54514 and GSE63042 were downloaded from the GEO database. DEGs were screened by t test after logarithmization of raw data; then, the common DEGs between the 2 gene expression profiles were identified by up-regulation and down-regulation intersection. The DEGs were analyzed using bioinformatics, and a protein-protein interaction (PPI) survival network was constructed using STRING. Survival curves were constructed to explore the relationship between core genes and the prognosis of sepsis patients based on GSE54514 data.<BR><B>RESULTS: </B>A total of 688 common DEGs were identified between survivors and non-survivors of sepsis, and 96 genes were involved in survival networks. The crucial genes Signal transducer and activator of transcription 5A (STAT5A), CCAAT/enhancer-binding protein beta (CEBPB), Myc proto-oncogene protein (MYC), and REL-associated protein (RELA) were identified and showed increased expression in sepsis survivors. These crucial genes had a positive correlation with patients' survival time according to the survival analysis.<BR><B>CONCLUSIONS: </B>Our findings indicate that the genes STAT5A, CEBPB, MYC, and RELA may be important in predicting the prognosis of sepsis patients.