%0 Journal Article
%T [What is the Best Initial Treatment for Parkinson's Disease? New Clinical Practice Guideline and My Personal Opinion].
%A Takeda A
%J Brain Nerve
%V 71
%N 8
%D Aug 2019
%M 31346142
暂无%R 10.11477/mf.1416201366
%X Over the last few decades, several delayed-start trials have suggested that early introduction of dopamine replacement therapy can improve the prognosis of Parkinson's disease (PD). Moreover, several observations support that L-dopa is non toxic to normal and diseased substantia nigra in humans. Thus, the clinical practice guideline 2018 for PD recommends L-dopa as an initial treatment for PD, in principle. More recently, several potential disease-modifying therapies have been reported to be effective. Furthermore, several recent studies suggest that exercise can be beneficial in delaying disease progression.