%0 Journal Article
%T Investigation of an outbreak of Burkholderia cepacia infection caused by drug contamination in a tertiary hospital in China.
%A Zou Q
%A Li N
%A Liu J
%A Li X
%A Wang Z
%A Ai X
%A Tao F
%A Qu M
%A Cai M
%A Hu Y
%J Am J Infect Control
%V 48
%N 2
%D 02 2020
%M 31345617
%F 4.303
%R 10.1016/j.ajic.2019.06.011
%X Contamination of drugs used in minimally invasive treatment may to lead to infection outbreaks and catastrophic public health events that require prompt detection and control. Our aim was to investigate the outbreak of Burkholderia cepacia infection and its source in a tertiary care, general hospital in Beijing, China.
We investigated the outbreak of B cepacia infection from January 2017 to March 2018. The investigation included a detailed review of all cases, and field investigations. Environmental and product cultures were performed at the microbiology laboratory in the hospital. Isolates were evaluated for molecular relatedness using pulsed-field gel electrophoresis performed in an independent laboratory.
In total, 9 patients were infected from November 2017 to March 2018, and all patients had undergone the following surgeries: transurethral resection of the prostate (n = 4), perineal prostate biopsy (n = 2), transurethral resection of bladder tumors (n = 2), and ureteroscopy (n = 1). B cepacia was isolated from the urine of 9 patients, blood of 2 patients, grilles used for puncturing, and 2 samples in 1 batch of analgesic gels. Pulsed-field gel electrophoresis confirmed that the isolates from the patients and gels were homologous.
Our investigation revealed that the outbreak of B cepacia infection was caused by drug contamination.