%0 Comparative Study
%T Comparison of toxicokinetic parameters of a drug and two metabolites following traditional and capillary microsampling in rat.
%A Verhaeghe T
%A Dillen L
%A Stieltjes H
%A Zwart L
%A Feyen B
%J Bioanalysis
%V 11
%N 13
%D Jun 2019
%M 31298569
%F 2.695
%R 10.4155/bio-2019-0085
%X Aim: Following the request of a regulatory authority, a rat study was conducted to compare pharmacokinetic parameters from traditional large volume sampling and capillary microsampling. Materials & methods: Rats were dosed with a proprietary compound in three dose groups and blood samples were collected via capillary microsampling (32 μl), immediately followed by traditional large volume sampling (300 μl) up to 24 h postdose. Resulting plasma samples were analyzed for parent drug and two metabolites. AUCs were compared between sampling techniques. Results: There was no statistical difference between AUCs from traditional and microsampling across different doses and analytes. Conclusion: Toxicokinetic parameters generated from plasma collected as a capillary microsample or traditional large volume sample are highly comparable.