%0 Journal Article
%T Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14.
%A Ferguson FM
%A Doctor ZM
%A Ficarro SB
%A Marto JA
%A Kim ND
%A Sim T
%A Gray NS
%J Bioorg Med Chem Lett
%V 29
%N 15
%D 08 2019 1
%M 31175010
%F 2.94
%R 10.1016/j.bmcl.2019.05.024
%X The TAIRE family of kinases are an understudied branch of the CDK kinase family, that have been implicated in a number of cancers. This manuscript describes the design, synthesis and SAR of covalent CDK14 inhibitors, culminating in identification of FMF-04-159-2, a potent, covalent CDK14 inhibitor with a TAIRE kinase biased selectivity profile.