%0 Journal Article
%T Acrokeratosis Can Be a Warning Sign of an Underlying Malignancy.
%A Nguyen S
%A Grosber M
%A Gutermuth J
%J Eur J Case Rep Intern Med
%V 6
%N 5
%D 2019
%M 31157185
暂无%R 10.12890/2019_001108
%X <B>UNASSIGNED: </B>Some cutaneous manifestations can be the first presentation of an underlying malignancy. These so-called paraneoplastic syndromes can sometimes be very subtle or strongly resemble other benign cutaneous diseases.<BR><B>UNASSIGNED: </B>In this report, we want to emphasize the need for further investigation of eczema-like cutaneous presentations which develop at a later age and are recalcitrant to therapy. Exclusion of an underlying malignancy needs to be considered.<BR><B>UNASSIGNED: </B>A 53-year-old man with thickening of the skin, more pronounced on the hands, feet and face, was diagnosed with classic nodular sclerosing Hodgkin disease based on cutaneous presentation.<BR><B>UNASSIGNED: </B>After two rounds of chemotherapy (adriamycin, bleomycin, vinblastine and dacarbazine), the cutaneous symptoms had disappeared. After six rounds of chemotherapy and 14 months of follow-up, the patient is still in remission without recurrence of the cutaneous symptoms.<BR><B>UNASSIGNED: </B>Cutaneous symptoms recalcitrant to adequate treatment should raise suspicion and prompt further investigation to exclude an underlying malignancy. A multidisciplinary approach with the dermatology department can accelerate diagnosis and improve the patient's prognosis.<BR><B>UNASSIGNED: </B>Skin diseases can reflect internal manifestations or diseases.Vigilance, timely recognition and a multidisciplinary approach are important in a patient with atypical cutaneous manifestations.A paraneoplastic skin syndrome should be considered in persistent skin disease not responding to treatment and starting in middle-aged patients with B symptoms.