%0 Journal Article
%T Diagnostic Performance of Ultrasound Patterns by K-TIRADS and 2015 ATA Guidelines in Risk Stratification of Thyroid Nodules and Follicular Lesions of Undetermined Significance.
%A Hong HS
%A Lee JY
%J AJR Am J Roentgenol
%V 213
%N 2
%D 08 2019
%M 31039023
%F 6.582
%R 10.2214/AJR.18.20961
%X OBJECTIVE. The objective of our study was to assess the malignancy rates of thyroid nodules in the cytologically determined subclass of atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) and to assess the diagnostic performance of ultrasound (US) patterns defined by the Korean Thyroid Imaging Reporting and Data System (K-TIRADS) and the 2015 American Thyroid Association (ATA) guidelines for risk stratification of AUS/FLUS nodules. MATERIALS AND METHODS. From January 2010 to December 2016, 1340 thyroid nodules were diagnosed as AUS/FLUS via fine-needle aspiration biopsy. Of these, 683 cytopathologically confirmed nodules were included in this study. Each nodule was assigned to a category and US pattern, as defined by the K-TIRADS and ATA guidelines. US patterns were compared between benign and malignant nodules, and malignancy rates were calculated according to the subclasses of AUS/FLUS nodules and the K-TIRADS and ATA guidelines. Predictors of malignancy were assessed using logistic regression analysis. RESULTS. The overall malignancy rate of AUS/FLUS nodules was 47.4% (324/683). There were significant differences in malignancy risk among the subclasses (p = 0.001). There were significant differences in malignancy rates according to US patterns, K-TIRADS categories, and ATA categories (p < 0.001). The malignancy rates in the K-TIRADS categories of benign, low, intermediate, and high suspicion were 0%, 1.99%, 34.66%, and 89.00%, respectively (p < 0.001). The malignancy rates in the ATA categories of benign, very low, low, intermediate, and high suspicion were 0%, 0%, 3.33%, 33.54%, and 87.67% (p < 0.001). CONCLUSION. AUS/FLUS nodules with a final diagnosis of malignancy had significantly higher rates of suspicious US features and different K-TIRADS and ATA categories than benign nodules. US categories by K-TIRADS and ATA guidelines can be useful in predicting malignancy and risk stratification, and management planning can be adjusted according to US pattern.