%0 Journal Article
%T Application of liposome membrane as the reaction field: A case study using the Horner-Wadsworth-Emmons reaction.
%A Shimanouchi T
%A Kitagawa Y
%A Kimura Y
%J J Biosci Bioeng
%V 128
%N 2
%D Aug 2019
%M 30827857
%F 3.185
%R 10.1016/j.jbiosc.2019.01.015
%X The properties of the liposome membrane as a reaction field were investigated by focusing on the Horner-Wadsworth-Emmons reaction as a case study. Use of the liposomes existing in the gel phase resulted in the enhanced activity of the substrates and furnished the products with same E/Z stereoselectivity as in the liposome-free system. The membrane environment in the gel phase most likely assisted the formation of adducts that induced selective generation of the E-isomer. The possible role of liposomes is to assist the proton removal from the reactant, rather than providing the basic interfacial environment.