%0 Journal Article
%T An LDI-MSI approach for targeted and untargeted differentiation and assessment of pharmaceutical formulations.
%A Falco LFG
%A Melo CFOR
%A de Oliveira DN
%A Guerreiro TM
%A Catharino RR
%J Talanta
%V 197
%N 0
%D May 2019 15
%M 30771993
%F 6.556
%R 10.1016/j.talanta.2018.12.044
%X Falsified, counterfeit and adulterated medicines are an endemic problem worldwide that results in both monetary and health-related losses. Developing fast and reliable methods that are able to present a timely result based on the drug's spectral profile is an effort that is sure to benefit those involved in the whole distribution chain. We propose herein a Laser Desorption/Ionization imaging-based method that provides simple and minimal sample preparation; this method is capable of providing specific markers that characterize adulterations, using as proof of concept one of the most adulterated drug products for oral use, sildenafil. Our approach is able to provide quality markers, which can be applied in the fast screening of any product within the same molecular class. This same strategy may be a useful alternative to provide accurate measurements with high specificity for unraveling contaminants and/or byproducts in virtually any given pharmaceutical product.