%0 Journal Article
%T Pregnancy outcomes following quinolone and fluoroquinolone exposure during pregnancy: A systematic review and meta-analysis.
%A Acar S
%A Keskin-Arslan E
%A Erol-Coskun H
%A Kaya-Temiz T
%A Kaplan YC
%J Reprod Toxicol
%V 85
%N 0
%D 04 2019
%M 30738954
%F 3.421
%R 10.1016/j.reprotox.2019.02.002
%X To investigate whether maternal exposure to quinolones, fluoroquinolones and specifically ciprofloxacin is associated with major malformations and other adverse pregnancy outcomes.<BR>MEDLINE/PubMed, Embase and Reprotox® databases were searched. Observational studies with an exposed and control group were included.<BR>Analysis of 8 cohort and 2 case-control studies showed no significant increases in rates of major malformations for quinolone (OR, 1.04; 95% CI 0.89-1.21), fluoroquinolone (RR, 0.89; 95% CI 0.70-1.14) and ciprofloxacin exposure (RR, 0.72; 95% CI 0.43-1.19). For fluoroquinolones, live birth rate was significantly decreased (RD, -0.04; 95% CI -0.08 to -0.01) whereas elective termination rate (RD, 0.04; 95% CI 0.02-0.05) was significantly increased.<BR>Quinolone, fluoroquinolone and ciprofloxacin exposure were not associated with a significant increase in major malformations and adverse pregnancy outcomes, other than significantly decreased live birth rate and increased elective termination rate which may be the indicators of misperceived teratogenic risk.