%0 Journal Article
%T Longitudinal multi-centre brain imaging studies: guidelines and practical tips for accurate and reproducible imaging endpoints and data sharing.
%A Wiseman SJ
%A Meijboom R
%A Valdés Hernández MDC
%A Pernet C
%A Sakka E
%A Job D
%A Waldman AD
%A Wardlaw JM
%J Trials
%V 20
%N 1
%D Jan 2019 7
%M 30616680
%F 2.728
%R 10.1186/s13063-018-3113-6
%X <B>BACKGROUND: </B>Research involving brain imaging is important for understanding common brain diseases. Study endpoints can include features and measures derived from imaging modalities, providing a benchmark against which other phenotypical data can be assessed. In trials, imaging data provide objective evidence of beneficial and adverse outcomes. Multi-centre studies increase generalisability and statistical power. However, there is a lack of practical guidelines for the set-up and conduct of large neuroimaging studies.<BR><B>METHODS: </B>We address this deficit by describing aspects of study design and other essential practical considerations that will help researchers avoid common pitfalls and data loss.<BR><B>RESULTS: </B>The recommendations are grouped into seven categories: (1) planning, (2) defining the imaging endpoints, developing an imaging manual and managing the workflow, (3) performing a dummy run and testing the analysis methods, (4) acquiring the scans, (5) anonymising and transferring the data, (6) monitoring quality, and (7) using structured data and sharing data.<BR><B>CONCLUSIONS: </B>Implementing these steps will lead to valuable and usable data and help to avoid imaging data wastage.