%0 Journal Article
%T p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.
%A Karras P
%A Riveiro-Falkenbach E
%A Cañón E
%A Tejedo C
%A Calvo TG
%A Martínez-Herranz R
%A Alonso-Curbelo D
%A Cifdaloz M
%A Perez-Guijarro E
%A Gómez-López G
%A Ximenez-Embun P
%A Muñoz J
%A Megias D
%A Olmeda D
%A Moscat J
%A Ortiz-Romero PL
%A Rodríguez-Peralto JL
%A Soengas MS
%J Cancer Cell
%V 35
%N 1
%D 01 2019 14
%M 30581152
%F 38.585
%R 10.1016/j.ccell.2018.11.008
%X Modulators of mRNA stability are not well understood in melanoma, an aggressive tumor with complex changes in the transcriptome. Here we report the ability of p62/SQSTM1 to extend mRNA half-life of a spectrum of pro-metastatic factors. These include FERMT2 and other transcripts with no previous links to melanoma. Transcriptomic, proteomic, and interactomic analyses, combined with validation in clinical biopsies and mouse models, identified a selected set of RNA-binding proteins (RBPs) recruited by p62, with IGF2BP1 as a key partner. This p62-RBP interaction distinguishes melanoma from other tumors where p62 controls autophagy or oxidative stress. The relevance of these data is emphasized by follow-up analyses of patient prognosis revealing p62 and FERMT2 as adverse determinants of disease-free survival.