%0 Journal Article
%T FKBP Ligands-Where We Are and Where to Go?
%A Kolos JM
%A Voll AM
%A Bauder M
%A Hausch F
%J Front Pharmacol
%V 9
%N 0
%D 2018
%M 30568592
%F 5.988
%R 10.3389/fphar.2018.01425
%X In recent years, many members of the FK506-binding protein (FKBP) family were increasingly linked to various diseases. The binding domain of FKBPs differs only in a few amino acid residues, but their biological roles are versatile. High-affinity ligands with selectivity between close homologs are scarce. This review will give an overview of the most prominent ligands developed for FKBPs and highlight a perspective for future developments. More precisely, human FKBPs and correlated diseases will be discussed as well as microbial FKBPs in the context of anti-bacterial and anti-fungal therapeutics. The last section gives insights into high-affinity ligands as chemical tools and dimerizers.