%0 Journal Article
%T Administration of systemic antibiotics during non-surgical periodontal therapy-a consensus report.
%A Pretzl B
%A Sälzer S
%A Ehmke B
%A Schlagenhauf U
%A Dannewitz B
%A Dommisch H
%A Eickholz P
%A Jockel-Schneider Y
%J Clin Oral Investig
%V 23
%N 7
%D Jul 2019
%M 30374830
%F 3.606
%R 10.1007/s00784-018-2727-0
%X <B>OBJECTIVE: </B>The aim of this meta-review was to evaluate whether there is a meaningful clinical benefit regarding the use of systemic adjunctive antibiotics in the treatment of patients with periodontitis. Additionally, a consensus regarding possible recommendations for future administration of antibiotics should be reached.<BR><B>METHODS: </B>A structured literature search was performed by two independent investigators focusing on systematic reviews (SR) covering adjunctive systemic antibiosis during non-surgical periodontal therapy. Additionally, recent randomized clinical trials (RCT, July 2015 to July 2017) were searched systematically to update the latest SR. Results were summarized and discussed in a plenary to reach a consensus.<BR><B>RESULTS: </B>Mostly, systematic reviews and RCTs showed a significant positive effect of adjunctive systematic antibiosis compared to controls. These positive effects gain clinical relevance in patients with severe periodontal disease aged 55 years and younger.<BR><B>CONCLUSIONS: </B>Systemic antibiotics as an adjunct to non-surgical periodontal therapy should be sensibly administered and restrictively used. Only certain groups of periodontitis patients show a significant and clinically relevant benefit after intake of systemic antibiosis during periodontal therapy.<BR><B>CONCLUSIONS: </B>Avoiding antibiotic resistance and possible side effects on the human microbiome should be a focus of dentists and physicians. Thus, a sensible administration of antibiotics is mandatory. This manuscript suggests guidelines for a reasonable use.