%0 Journal Article
%T Williams-Beuren Syndrome as a Potential Risk Factor for Burkitt Lymphoma.
%A Kimura R
%A Ishii Y
%A Tomiwa K
%A Awaya T
%A Nakata M
%A Kato T
%A Okazaki S
%A Heike T
%A Hagiwara M
%J Front Genet
%V 9
%N 0
%D 2018
%M 30233648
%F 4.772
%R 10.3389/fgene.2018.00368
%X Williams-Beuren syndrome (WBS) is a multisystemic neurodevelopmental disorder caused by a hemizygous deletion on chromosome 7q11.23. Though at present there is a limited number of reports on WBS patients with tumors, most cases are related to blood cancer in children with WBS. We describe a case of Burkitt lymphoma in a 21-year-old man with WBS. In addition to providing a summary of published reports describing tumors observed in patients with WBS, we present a hypothesis about a possible mechanism of oncogenesis. In particular, we identified some significantly dysregulated cancer-related genes using blood samples from this patient at the age of 19 years (who have not yet developed Burkitt lymphoma). Our findings may provide a new perspective on the relation between WBS and Burkitt lymphoma.