%0 Journal Article
%T Glycolysis Inhibitors Monoiodoacetate and 2-Deoxyglucose as Antitumor Agents: Experimental Study on Lewis Lung Carcinoma Model.
%A Korshunov DA
%A Klimov IA
%A Ivanov VV
%A Kondakova IV
%J Bull Exp Biol Med
%V 165
%N 5
%D Sep 2018
%M 30225703
%F 0.737
%R 10.1007/s10517-018-4244-1
%X Antitumor effects of glycolysis inhibitors monoiodoacetate and 2-deoxyglucose were studied on Lewis lung carcinoma model. Monoiodoacetate exhibited antitumor and antimetastatic activities, being not inferior of methotrexate (reference drug); however, the preparation also demonstrated high systemic toxicity. 2-Deoxyglucose exhibited only antitumor effect, while its antimetastatic activity did not differ from the result in the group without treatment.