%0 Journal Article
%T Preliminary randomized controlled trial of antiaging effects of l-ascorbic acid applied in combination with no-needle and microneedle mesotherapy.
%A Zasada M
%A Markiewicz A
%A Drożdż Z
%A Mosińska P
%A Erkiert-Polguj A
%A Budzisz E
%J J Cosmet Dermatol
%V 18
%N 3
%D Jun 2019
%M 30070034
%F 2.189
%R 10.1111/jocd.12727
%X <B>BACKGROUND: </B>The epidermis is keratinized stratified squamous epithelium covered by hydro-lipid barrier. Vitamin C is a water-soluble antioxidant which protects skin from oxidative damage and rejuvenates photo-aged skin. There are different options of improving active substance penetration through the stratum corneum of the epidermis. One of them is noneedle mesotherapy which is a non-invasive rejuvenation technique involving electric pulses, electroporation, and ultrasounds. The use of these physicals factors results in deeper penetration of active ingredients. The other one is micro-needle mesotherapy which is nonsurgical therapy, which could cause the controlled inflammation. Micro channels are formed by needles during the skin puncture, that facilitate penetration of the active ingredients.<BR><B>OBJECTIVE: </B>The aim of the study was to assess the efficacy of L-ascorbic acid applied in combination with no-needle and micro-needle mesotherapy in anti-aging therapy.<BR><B>METHODS: </B>This study involved 17 healthy volunteers, 2.5 ml of serum containing 20% L-ascorbic acid with hydrate from strawberries was used topically in every of 4 treatments. No-needle mesotherapy was applied on the left half of the face while microneedle mesotherapy in combination with the same serum was performed on the right half of face.<BR><B>RESULTS: </B>In vivo studies confirmed the effectiveness of both methods.<BR><B>CONCLUSIONS: </B>The impact of active substance on skin firmness and elasticity as well as the degree of hydration and skin tone was more efficient after micro-needle mesotherapy.