%0 Journal Article
%T Integrating genome-wide association study, chromosomal enhancer maps and element-gene interaction networks detected brain regions related associations between elements and ADHD/IQ.
%A Ma M
%A Liang X
%A Cheng S
%A Zhang L
%A Cheng B
%A Yang J
%A Ding M
%A Zhao Y
%A Li P
%A Du Y
%A Liu L
%A Wen Y
%A He A
%A Fan Q
%A Guo X
%A Zhang F
%J Behav Brain Res
%V 353
%N 0
%D 11 2018 1
%M 30016737
%F 3.352
%R 10.1016/j.bbr.2018.07.008
%X To explore the associations between chemical elements and attention deficit hyperactivity disorder (ADHD)/intelligence quotient (IQ).<BR>We applied elements related gene set enrichment analysis (ERGSEA) to explore the relationships between elements and ADHD/IQ. The GWAS dataset of ADHD was derived from the Psychiatric Genomics Consortium, involving 55,374 individuals. The GWAS dataset of IQ was derived from UK Biobank web-based measure (n = 17,862), UK Biobank touchscreen measure (n = 36,257), CHIC consortium (n = 12,441) and five additional cohorts (n = 11,748). Enhancer-gene datasets of eight brain tissues consist of 935 individuals. Utilizing the published GWAS summary and eight brain region-related chromosomal enhancer maps to obtain the SNP association testing signals. The element-gene interaction datasets of 21 elements were downloaded from the comparative toxicogenomics database (CTD).<BR>ERGSEA observed significant associations between 4 elements and ADHD, such as Al at Hippocampus Middle (P value = 0.040), As at Angular Gyrus (P value = 0.007) and Na at Hippocampus Middle (P value = 0.026). Additionally, ERGSEA identified that 5 elements were associated with IQ, mainly including Al at Dorsolateral Prefrontal Cortex (P value = 0.017), As at Dorsolateral Prefrontal Cortex (P value = 0.004) and Pb at Germinal Matrix (P value = 0.045).<BR>Our study results provide novel clues for understanding the associations between elements and ADHD/IQ. This study also illustrated the good performance of ERGSEA approach for complex diseases.