%0 Journal Article
%T Analysis of miRNA expression profiling identifies miR-214-3p as a novel biomarker in sinonasal inverted papilloma.
%A Teng Y
%A Li Y
%A Lin Z
%A Gao Y
%A Cao X
%A Lou X
%A Lin F
%A Li Y
%J Epigenomics
%V 10
%N 12
%D Dec 2018
%M 29952653
%F 4.357
%R 10.2217/epi-2018-0071
%X <B>OBJECTIVE: </B>To analyze the expression profile, diagnostic and clinicopathological significances of miRNAs in sinonasal inverted papilloma (SNIP).<BR><B>METHODS: </B>The expression profile of miRNAs was analyzed using a miRNA microarray approach. The potential functions and clinical significances of specific miRNAs were further analyzed by bioinformatics and statistical methods.<BR><B>RESULTS: </B>The microarray assay identified 37 significantly upregulated and 21 downregulated miRNAs in SNIP. Of nine miRNAs randomly selected, the expression levels of seven miRNAs were confirmed by quantitative real-time PCR. The potential target genes of several candidate miRNAs were enriched in some biological processes and cellular signaling pathways related to tumorigenesis. Receiever operating characteristic curve analysis for miR-214-3p indicated an area under the curve of 0.932. Notably, its expression level was significantly decreased in SNIP tissues and associated with SNIP staging and recurrence.<BR><B>CONCLUSIONS: </B>MiR-214-3p can possibly serve as a valuable biomarker and a therapeutic target for SNIP.