%0 Journal Article
%T Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review.
%A Turnaturi R
%A Montenegro L
%A Marrazzo A
%A Parenti R
%A Pasquinucci L
%A Parenti C
%J Eur J Med Chem
%V 155
%N 0
%D Jul 2018 15
%M 29908442
%F 7.088
%R 10.1016/j.ejmech.2018.06.017
%X Despite the fact that the benzomorphan skeleton has mainly been employed in medicinal chemistry for the development of opioid analgesics, it is a versatile structure. Its stereochemistry, as well as opportune modifications at the phenolic hydroxyl group and at the basic nitrogen, play a pivotal role addressing the benzomorphan-based compounds to a specific target. In this review, we describe the structure activity-relationships (SARs) of benzomorphan-based compounds acting at sigma 1 receptor (σ1R), sigma 2 receptor (σ2R), voltage-dependent sodium channel, N-Methyl-d-Aspartate (NMDA) receptor-channel complex and other targets. Collectively, the SARs data have highlighted that the benzomorphan nucleus could be regarded as a useful template for the synthesis of drug candidates for different targets.