%0 Comparative Study
%T Pirfenidone Accelerates Wound Healing in Chronic Diabetic Foot Ulcers: A Randomized, Double-Blind Controlled Trial.
%A Gasca-Lozano LE
%A Lucano-Landeros S
%A Ruiz-Mercado H
%A Salazar-Montes A
%A Sandoval-Rodríguez A
%A Garcia-Bañuelos J
%A Santos-Garcia A
%A Davila-Rodriguez JR
%A Navarro-Partida J
%A Bojórquez-Sepúlveda H
%A Castañeda-Gomez J
%A Domínguez-Rosales J
%A Ruiz-Arcos MA
%A Sánchez-Parada MG
%A Armendariz-Borunda J
%J J Diabetes Res
%V 2017
%N 0
%D 2017
%M 29675430
暂无%R 10.1155/2017/3159798
%X <B>UNASSIGNED: </B>Diabetic foot ulcers are one disabling complication of diabetes mellitus. Pirfenidone (PFD) is a potent modulator of extracellular matrix. Modified diallyl disulfide oxide (M-DDO) is an antimicrobial and antiseptic agent.<BR><B>UNASSIGNED: </B>To evaluate efficacy of topical PFD + M-DDO in a randomized, double-blind trial versus ketanserin in the treatment of noninfected chronic DFU.<BR><B>UNASSIGNED: </B>Patients received PFD + M-DDO or ketanserin for 6 months. Relative ulcer volume (RUV) was measured every month; biopsies were taken at baseline and months 1 and 2 for histopathology and gene expression analysis for COL-1α, COL-4, KGF, VEGF, ACTA2 (α-SMA), elastin, fibronectin, TGF-β1, TGF-β3, HIF-1α, and HIF-1β.<BR><B>UNASSIGNED: </B>Reduction of median RUV in the PFD + M-DDO group was 62%, 89.8%, and 99.7% at months 1-3 and 100% from months 4 to 6. Ketanserin reduced RUV in 38.4%, 56%, 60.8%, 94%, 94.8%, and 100% from the first to the sixth month, respectively. Healing score improved 4.5 points with PFD + M-DDO and 1.5 points with ketanserin compared to basal value. Histology analysis revealed few inflammatory cells and organized/ordered collagen fiber bundles in PFD + M-DDO. Expression of most genes was increased with PFD + M-DDO; 43.8% of ulcers were resolved using PFD + M-DDO and 23.5% with ketanserin.<BR><B>UNASSIGNED: </B>PFD + M-DDO was more effective than ketanserin in RUV reduction.