%0 Journal Article
%T The likelihood of achieving pregnancy through timed coitus in young infertile women with decreased ovarian reserve.
%A Koo HS
%A Song IO
%A Cha SH
%A Park CW
%A Kim HO
%J Clin Exp Reprod Med
%V 45
%N 1
%D Mar 2018
%M 29662823
暂无%R 10.5653/cerm.2018.45.1.31
%X <B>UNASSIGNED: </B>To evaluate the pregnancy rate and time to pregnancy after timed coitus with or without superovulation in infertile young women younger than 35 years old with low serum anti-Müllerian hormone (AMH) levels (<25th percentile).<BR><B>UNASSIGNED: </B>A total of 202 patients younger than 35 years old were recruited retrospectively between 2010 and 2012. Ninety-eight women had normal serum AMH levels (25-75th percentile), 75 women had low serum AMH levels (5th≤&<25th percentile) and 29 women had very low serum AMH levels (<5th percentile), according to reference values for their age group.<BR><B>UNASSIGNED: </B>The clinical pregnancy rate was positively associated with AMH levels, but this trend did not reach statistical significance (43.9% vs. 41.3% vs. 27.6% in the normal, low, and very low AMH groups, respectively). The time to pregnancy was longer in the very low AMH group than in the normal AMH group (13.1±10.9 months vs. 6.9±6.1 months, p=0.030). The cumulative live birth rate over 18 months was lower in the very low AMH group than in the normal AMH group, with marginal significance (20.0% vs. 55.9%, p=0.051). The duration of infertility was negatively correlated with achieving pregnancy (odds ratio, 0.953; 95% confidence interval, 0.914-0.994; p=0.026).<BR><B>UNASSIGNED: </B>Conservative management, such as timed coitus with or without superovulation, should be considered in young patients who have low ovarian reserve without any infertility factors. However, for women with a long duration of infertility or very low serum AMH levels, active infertility treatment should be considered.