%0 Journal Article
%T Guidelines for prophylaxis of Pneumocystis pneumonia cannot rely solely on CD4-cell count in autoimmune and inflammatory diseases.
%A Baulier G
%A Issa N
%A Gabriel F
%A Accoceberry I
%A Camou F
%A Duffau P
%J Clin Exp Rheumatol
%V 36
%N 3
%D May-Jun 2018
%M 29533748
%F 4.862
%R 
%X <B>OBJECTIVE: </B>Guidelines for preventing Pneumocystis pneumonia (PCP) in HIV patients are based on CD4 below 200/mm3. Such cut-off value is suggested to guide prophylaxis in non-HIV conditions (NHIV) especially in autoimmune and inflammatory diseases (AD). We aimed to determine if CD4 could be used to guide PCP prophylaxis in AD.<BR><B>METHODS: </B>CD4 and lymphocyte-count were retrospectively studied in patients diagnosed with PCP between January 2013 and February 2016.<BR><B>RESULTS: </B>129 patients were included. The median CD4-count was 302/mm3 in AD, which was significantly higher than in HIV patients (19/mm3; p<0.0001). Fifty percent (n=10) of AD patients had CD4 counts greater than 300/mm3.<BR><B>CONCLUSIONS: </B>Prophylaxis for PCP cannot rely solely on CD4-count in NHIV patients especially in AD.