%0 Case Reports
%T Medulloblastoma in association with sacral agenesis; a case report.
%A Soltani ZE
%A Habibi Z
%A Nejat F
%J Childs Nerv Syst
%V 34
%N 6
%D 06 2018
%M 29404676
%F 1.532
%R 10.1007/s00381-018-3737-6
%X Medulloblastoma is a congenital brain tumor which can be associated with different congenital anomalies. However, coincidence of cerebellar medulloblastoma with sacral agenesis has not been reported so far. A variety of genetic and/or environmental predisposing factors have been proposed for both diseases. Herein, an unprecedented coincidence of these two conditions is presented. A neonate was born with lumbosacral agenesis, paraplegia, and atrophic legs, and he developed medulloblastoma with three ventricular hydrocephalus 3 years later. Different aspects regarding the embryology and etiology of both ailments are discussed, assuming the possibility that the same genetic and/or environmental risk factors may have played a part in both conditions.