%0 Journal Article
%T [Clinical and radiological characteristics of pulmonary tuberculosis in tobacco smokers].
%A Kombila UD
%A Mbaye FBR
%A Dia Kane Y
%A Ka W
%A Toure Badiane NO
%J Rev Mal Respir
%V 35
%N 5
%D May 2018
%M 29395566
%F 0.714
%R 10.1016/j.rmr.2017.04.006
%X <B>BACKGROUND: </B>Tobacco smoke alters lung defense mechanisms against infections and so increases the risk of mycobacterium tuberculosis infection.<BR><B>OBJECTIVE: </B>To determine the particular clinical features of tuberculosis in smokers and identify risk factors.<BR><B>METHODS: </B>We conducted a prospective, cross-sectional study over a period of nine months in Dakar, Senegal. The Chi-square test and multiple logistic regression were used to identify differences between smokers and non-smokers and to identify factors associated with clinical outcomes.<BR><B>RESULTS: </B>We included 165 patients with active pulmonary tuberculosis (59 smokers versus 106 never-smokers). The average age of smokers was 43.8±12.7 versus 32.1±13.1 years (P<0.0001). Smokers were overwhelmingly male (98.3% versus 1.8%, P<0.0001). The average delay to consultation was longer among smokers (90 days [30-120] versus 60 days [30-90] ; P<0.0001). In multivariate analysis, alcohol abuse, increasing age, male sex, and an unknown retroviral status were independent risk factors for pulmonary tuberculosis. Haemoptysis was observed more frequently in smokers (49.1% versus 31.1%, P=0.017). With regards to chest X-ray features, smokers presented with more advanced, bilateral and cavitating lung lesions.<BR><B>CONCLUSIONS: </B>Diagnostic delay and haemoptysis are important characteristics of the pulmonary tuberculosis in tobacco smokers.