%0 Journal Article
%T DNA damage in acute myeloid leukemia patients of Northern Mexico.
%A Dávila-Rodríguez MI
%A Cortés-Gutiérrez EI
%A Hernández-Valdés R
%A Guzmán-Cortés K
%A De León-Cantú RE
%A Cerda-Flores RM
%A Báez-De la Fuente E
%J Eur J Histochem
%V 61
%N 4
%D Dec 2017 11
%M 29313600
%F 1.966
%R 10.4081/ejh.2017.2851
%X The purpose of this study was to evaluate DNA damage in the whole genome of peripheral blood leukocytes from patients with acute myeloid leukemia (AML) compared with a control group using DNA breakage detection-fluorescent in situ hybridization (DBD-FISH). Our results suggest that the DNA damage detected in patients with newly diagnosed AML was similar to that observed for the controls; this might be explained by the stimulation of a repair pathway by the pathogenesis itself. These findings indicate that inhibiting the repair pathway could be proposed to enhance the efficacy of chemotherapy.